学习经历
   1981.09-1985.07 河北师范大学生物学，本科学生，获得理学学士学位
   1988.09-1991.06 河北师范大学，硕士研究生，获得理学硕士学位
   1998.01-2001.06 美国普渡大学园艺系博士研究生，获得博士学位
           

工作经历
   1985.07-1988.08 河北师范大学生物系（现生命学院）党总支秘书
   1991.06-1992.06 河北师范大学生物系，助教
   1992.06-1995.08 河北师范大学生物系，讲师，植物教研室副主任
   1995.09-1997.12 美国普渡大学生物系和园艺系，访问学者
   2001.06-2004.02 美国夭科特烟草公司，科学家（研究员）
   2004.03-2015.08 中国科学院遗传与发育生物学研究所和植物细胞和染色体工程国家重点实 验室，研究员，博士生导师。农业资源研究中心副主任，中心学术委员会主任
   2015.9-至今 华中农业大学，永利集团88304官网, 教授,博士生导师
           

主要研究方向
         
 1.大豆共生固氮调控机理研究
 大豆是重要的经济作物，是植物蛋白和油脂的主要来源。大豆可以和根瘤菌共生形成根瘤，进而把空气中的N2转化为植物可以利用的NH3。大豆根瘤的发育和固氮效率的高低是影响大豆产量和品质的关键因素。本课题组利用生理生化、分子生物学、遗传学等综合研究方法对大豆根瘤发育和固氮效率及其对非生物胁迫响应的分子机制进行系统性研究，重点研究大豆miRNA及靶基因影响大豆根瘤发育和固氮效率的分子调控网络。旨在解析豆科植物共生固氮的分子机制，为分子设计培育高效固氮的高产优质豆科植物新品种提供科学依据。
         
 2.植物耐逆和可塑性发育分子机制研究
 植物对逆境响应以及抗逆的分子机制是一个重要的生物学问题，涉及到植物在逆境下的可塑性发育、基础代谢以及植物细胞、组织和个体得能量、水分、离子、氧化还原物的稳态的调控等生物学过程。本课题组将以模式植物拟南芥和大豆为材料，采用综合研究手段探究植物对非生物逆境尤其抗盐碱和干旱响应的生理和遗传机理，重点是植物根系发育对逆境适应和调控分子网络，逆境条件下植物防御代谢的转换的机制。最终目标是揭示植物抗逆的分子机理，创建耐盐抗旱节水新作物品系。

（1） 过表达miR156b促进大豆高产和稳产，主持人，转基因生物新品种培育重大专项，2020.01-2020.12

（2） 豆科植物根瘤菌侵染及在胞内定殖，主持人，国家自然科学基金，2020.01-2022.12

（3） 共生固氮信号转导模块及其丰豆科转移机制，重大研发计划，任务负责人，2020.1-2024.12

（4） miR172c/NNC1模块调控大豆共生固氮和生长发育分子机理研究，主持人，国家自然科学基金重点项目，2018-2022 年

发明专利

（1）李霞，董章辉，石磊。一种与植物耐盐性相关的miRNA gma-miRN60及其应用, 专利号：ZL201110155710.8
（2）李霞，董章辉，石磊。一种与植物耐盐性相关的miRNA gma-miRN305及其应用，专利号：ZL201110155808.3
（3）李霞，邹艳敏，王幼宁，陈亮，石磊，李东晓，王延伟。一种培育转基因固氮植物的方法，专利号：ZL 201110155347.X
（4）李霞，董章辉，石磊。一种与植物耐盐性相关的miRNA gma-miRN39及其应用，专利号：ZL201110155765.9
（5）李霞，董章辉。一种培育转基因耐寒植物的方法，专利号：ZL201110154784.X
（6）李霞，王幼宁，陈亮，石磊，李东晓。一种与植物耐低温相关的基因及其应用。专利号：ZL 201110155245.8
（7）李霞，王涛，王志娟。ABA和盐相关蛋白STS1和编码基因及应用，专利号：ZL201010590264.9
（8）李霞，赵彦坤，纪洪涛，王幼宁。 植物耐逆性相关蛋白GUI及其编码基因和应用，专利号：ZL 201010594990.8
（9）李霞，纪洪涛，王幼宁。植物耐低温蛋白TCF1及编码基因和应用，专利号：ZL 201010585989.9
（10）李霞，罗焱杰，纪洪涛，王志娟。植物耐逆性相关蛋白IMBE1及其编码基因和应用，专利号：ZL 201210090545.7
（11）李霞；王幼宁；陈亮；李科学。一种促进植物结瘤固氮的microRNA及其应用。专利申请号：20140003296.2
（12）李霞；王幼宁；陈亮；李科学；邹艳敏；王蕊。一种RNA干扰载体及其培育高结瘤固氮植物的应用。 专利号：ZL 201410005361.5
（13）李霞；王幼宁；邹艳敏；陈亮。RNA干扰载体片段、RNA干扰载体及其应用。专利号：ZL 201410003298.1
（14）李霞；王幼宁；纪洪涛；姜琼；赵芳；石磊；杜琳倩。一种过表达gma-miR156b培育高产株型植物的方法。专利申请号：201410478207X
         
获得奖励
         
2014年 获得中国科学院遗传发育所2014年度“优秀团队奖”
2014年 获得河北省省直“三八红旗集体”荣誉称号
2011年 “盐胁迫下植物根系构型可塑性发育的生理和分子机理”获得河北省自然科学奖三等奖，第一完成单位
2009年 获得中国科学院“朱李月华优秀教师奖”
2008年 获得“河北省女职工建功立业标兵”荣誉称号
2004年 至今多次评为中心优秀个人和团队奖

发表的论文及著作 （#共同第一作者，*通讯作者）

1. Wang Z#, Ren Z#, Cheng C#, Wang T#, Ji H, Zhao Y, Deng Z, Zhi L, Lu J, Wu X, Cao M, Zhao H, Liu L, Zhu J-K, Li X*. (2020). Counteraction of ABA-mediated inhibition of seed germination and seedling establishment by ABA signaling terminator in Arabidopsis. Molecular Plant DOI: https://doi.org/10.1016/j.molp.2020.06011.

2. Han Q, Ma Q, Chen Y, Tian B, Xu L, Bai Y*, Chen W*, Li X*. (2020). Variation in rhizosphere microbial communities and its association with the symbiotic efficiency of rhizobia in soybean. ISME Journal 14: 1915-1928.  

3. Yao Y, You Q, Duan G, Ren J, Chu S, Zhao J, Li X*, Zhou X*, Jiao Y*. (2020). Quantitative trait loci analysis of seed oil content and composition of wild and cultivated soybean. BMC Plant Biology 20: 51.  

4. Wang Z, Wang L, Wang Y, Li X*. (2020). The NMN module conducts nodule number orchestra. iScience 23: 100825.

5. Wang ZJ, Liu L, Cheng C, Ren Z, Xu S, Li X*. (2020). GAI functions in the plant response dehydration stress in Arabidopsis thaliana. International Journal of Molecular Sciences. 21:819.

6. Cao JS, Li GJ, Qu DJ, Li X, Wang YN*. (2020). Into the seed: auxin controls seed development and grain yield. International Journal of Molecular Sciences, 21: 1662.

7. Wang LX, Sun ZX, Su C, Wang YL, Yan QQ, Chen JH, Ott T, Li X*. (2019). A GmNINa-miR172c-NNC1 regulatory network coordinates the nodulation and autoregulation of nodulation pathways in soybean. Molecular Plant 12: 1211-1226.

8. Wang YN, Yang W, Zuo YY, Zhu L, Hastwell AH, Chen L, Tian Y, Su C, Ferguson BJ, Li X*. (2019). GmYUC2a mediates auxin biosynthesis during root development and nodulation in soybean. Journal of Experimental Botany 70: 3165-3176.

9. Ullah I, Magdy M, Wang LX, Liu MY, Li X*. (2019). Genome-wide identification and evolutionary analysis of TGA transcription factors in soybean. Scientific Reports 9: 11186.

10. Bao A, Chen H, Chen L, Chen S, Hao Q, Guo W, Qiu D, Shan Z, Yang Z, Yuan S, Zhang C, Zhang X, Liu B, Kong F, Li X, Zhou X, Tran LP, Cao D. (2019) CRISPR/Cas9-mediated targeted mutagenesis of GmSPL9 genes alters plantarchitecture in soybean. BMC Plant Biology. 8;19(1):131.

11. Sun ZX, Su C, Yun JX, Jiang Q, Wang LX, Wang YN, Cao D, Zhao F, Zhao QS, Zhang MC, Zhou B, Zhang L, Kong FJ, Liu BH, Tong YP, Li X*. (2018). Genetic improvement of the shoot architecture and yield in soybean plants via the manipulation of GmmiR156b. Plant Biotechnology Journal 17: 50-62.

12. Yan Q, Wang LX, Li X*. (2018). GmBEHL1, a BES1/BZR1 family protein, negatively regulates soybean nodulation. Scientific Reports 8: 7614.

13. Ji HT, Wang SF, Cheng CH, Li R, Wang ZJ, Jenkins GI, Kong FJ, Li X*. (2018). The RCC1 family protein SAB1 negatively regulates ABI5 through multidimensional mechanisms during post-germination in Arabidopsis. New Phytologist 222: 907-922.

14. Tang T, Yu XW, Yang H, Gao Q, Ji HT, Wang YX, Yan GB, Peng Y, Luo HF, Liu KD, Li X, Ma CZ, Kang CY, Dai C. (2018). Development and validation of an effective CRISPR/Cas9 vector for efficiently isolating positive transformants and transgene-free mutants in a wide range of plant species. Frontier in Plant Science 9: 1533.

15. Cai ZM#, Wang YN#, Zhu L, Tian YP, Chen L, Sun ZX, Ullah I, Li X*. (2017). GmTIR1/GmAFB3-based auxin perception regulated by miR393 modulates soybean nodulation, New Phytologist 215: 672-686.

16. Hussain RM, Ali M, Feng X, Li X* (2017). The essence of NAC gene family to the cultivation of drought-resistant soybean (Glycine max L. Merr.) cultivars. BMC Plant Biology 17: 55.

17. Sahito ZA, Wang L, Sun Z, Yan QQ, Zhang XK, Jiang Q, Ullah I, Tong YP, Li X*. (2017). The miR172c-NNC1 module modulates root plastic development in response to salt in soybean. BMC Plant Biology 17: 229.

18. Wang YN, Yuan JH, Yang W, Zhu L, Su C, Wang XD, Wu HY, Sun ZX, Li X*. (2017). Genome wide identification and expression profiling of ethylene receptor genes during soybean nodulation. Frontier in Plant Science 8: 859.

19. Cheng CH, Wang ZJ, Ren ZY, Zhi LY, Yao B, Su C, Liu L, Li X*. (2017). SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana. PLoS Genetics 13: e1006947.

20. Cheng CH, Wang ZJ, Yuan BJ, Li X*. (2017). RBM25 mediates abiotic responses in Plants. Frontier in Plant Science 8: 292.

21. Zheng X, Liu HP, Ji HT, Wang YN, Dong BD, Qiao YZ, Liu MY*, Li X*. (2016). The wheat GT factor TaGT2L1D negatively regulates drought tolerance and plant development. Scientific Reports 6: 27042.

22. Su C#, Liu L#, Liu HP, Ferguson BJ, Zou YM, Zhao YK, Wang T, Wang YN*, Li X*. (2016). H2O2 regulates root system architecture by modulating the polar transport and redistribution of auxin. Journal of Plant Biology 59: 260-270.

23. Sun ZX#, Wang YN#, Mou FP, Tian YP, Chen L, Zhang SL, Jiang Q, Li X*. (2016). Genome- wide small RNA analysis of soybean reveals auxin-responsive microRNAs that are differentially expressed in response to salt stress in root apex. Frontier in Plant Science 6: 1273.

24. Wang ZJ, Ji HT, Yuan BJ, Wang SF, Yao BJ, Su C, Li X*. (2015). ABA signalling is fine-tuned by antagonistic HAB1 variants. Nature Communications 6: 8138.

25. Ji HT, Wang YN, Cloix C, Li KX, Jenkins JI, Wang SF, Shang ZL, Shi Y, Yang SH, Li X*. (2015). The Arabidopsis RCC1 family protein TCF1 regulates freezing tolerance and cold acclimation through modulating lignin biosynthesis. PLoS Genetics 11: e1005471.

26. Cao D, Li Y, Wang Y, Nan H, Wang Y, Lu S, Jiang Q, Li X, Shi D, Fang C, Yuan X, Zhao X, Li X*, Liu B*, Kong F*. (2015). GmmiR156b overexpression delays flowering time in soybean. Plant Molecular Biology 89: 353-363.

27. Wang YN, Li KX, Zhang SL, Chen L, Zou YM, Liu HP, Li DX, Wang R, Tian YP, Zhao F, Ferguson BJ, Gresshoff PM, Li X*. (2015). MicroRNA167-directed regulation of the auxin response factors, GmARF8a and GmARF8b, is required for soybean (Glycine max L.) nodulation and lateral root development. Plant Physiology 168: 101-116.

28. Wang YN, Wang LX, Zou YM, Chen L, Cai ZM, Zhang SL, Zhao F, Tian YP, Jiang Q, Ferguson B, Gresshoff P, Li X*. (2014). Soybean miR172c targets the repressive AP2 transcription factor NNC1 to activate ENOD40 expression and regulate nodule initiation. Plant Cell 26: 4782-4801.

29. Ji HT, Wang SF, Li KX, Szakonyi D, Koncz C, Li X*. (2014). PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis. Plant Journal 81: 399-412.

30. Ji HT, Liu L, Li KX, Xie Q, Wang ZJ, Zhao XH, Li X*. (2014). PEG-mediated osmotic stress induces premature differentiation of the root apical meristem and outgrowth of lateral roots in wheat. Journal of Experimental Botany 65: 4863-4872.

31. Kong D, Li M, Dong Z, Ji H, Li X*. (2014). Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses. Plant Cell Report 34: 395-410.

32. Zhang SL, Wang YN, Li KX, Zou YM, Chen L, Li X*. (2014). Identification of cold-responsive miRNAs and their target genes in nitrogen-fixing nodules of soybean. International Journal of Molecular Sciences 15: 13596-13614.

33. Luo YJ, Wang ZJ, Ji HT, Fang H, Wang SF, Tian LN, Li X*. (2013). An Arabidopsis homolog of importin beta 1 is required for ABA response and drought tolerance. Plant Journal 75: 377-389.

34. Zou YM, Wang YN, Wang LX, Yang L, Wang R, Li X*. (2013). miR172b controls the transition to autotrophic development inhibited by ABA in Arabidopsis. PLoS ONE 23: e64770.

35. Li DX, Liu HL, Qiao YZ, Wang YN, Cai ZM, Dong BD, Shi CH, Liu YY, Li X*, Liu MY*. (2013). Effects of elevated CO₂ on the growth, seed yield, and water use efficiency of soybean (Glycine max (L.) Merr.) under drought stress. Agricultural Water Management 129: 105-112.

36. Dong ZH, Shi L, Wang YW, Chen L, Cai ZM, Wang YN, Jin JB, Li X*. (2013). Identification and dynamic regulation of microRNAs involved in salt stress responses in functional soybean nodules by high-throughput sequencing. International Journal of Molecular Sciences 14: 2717-2738.

37. Peng Y, Ma W, Chen L, Yang L, Li S, Zhao H, Zhao Y, Jin W, Li N, Bevan MW, Li X, Tong Y, Li Y. (2013). Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 16: 1542-1556.

38. Zhao H, Liu L, Mo H, Qian L, Cui S, Li X, Ma L*. (2013). The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE 8: e60809.

39. Ji H, Pardo JM, Batelli G, Van Oosten MJ, Bressan RA, Li X*. (2013). The salt overly sensitive (SOS) pathway: established and emerging roles. Molecular Plant 6: 275-286.

40. Zhao H, Wang X, Zhu D, Cui S, Li X, Cao Y, Ma L*. (2012). A single amino acid substitution in IIIf subfamily of basic Helix-Loop-Helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry 287: 14109-14121.

41. Hao L, Wang W, Chen C, Wang Y, Liu T, Li X, Shang Z. (2012). Extracellular ATP promotes stomatal opening of Arabidopsis thaliana through heterotrimeric G protein a subunit and reactive oxygen species. Molecular Plant 5: 852-864.

42. Zhao Y, Wang T, Zhang W, Li X*. (2011). SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134.

43. Cao M, Li X*. (2010). Die for living better: Plants modify root system architecture through inducing PCD in root meristem under severe water stress. Plant Signaling & Behavior 5: 1-2.

44. Orsini F, D'Urzo MP, Inan G, Serra S, Oh DH, Mickelbart MV, Consiglio F, Li X, Jeong JC, Yun DJ, Bohnert HJ, Bressan RA, Maggio A. (2010). A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana. Journal of Experimental Botany 61: 3787-3798.

45. Zhao Y, Wang T, Zhang W, Li X*. (2010). SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134.

46. Duan Y, Zhang W, Li B, Wang Y, Li K, Sodmergen, Han C, Li X*. (2010). An ER response pathway mediates programmed cell death of root tip induced by water stress in Arabidopsis. New Phytologist 186: 681-695.

47. Xu J, Yin H, Liu X, Li X*. (2010). Salt affects plant Cd-stress responses by modulating growth and Cd accumulation. Planta 231: 449-459.

48. Xie Q, Yan X, Liao X, Li X*. (2009). The arsenic hyperaccumulator fern Pteris vittata L. Environmental Science & Technology 43: 8488-8495.

49. Xu J, Yin H, Li X*. (2009). Protective effects of proline against cadmium toxicity in micropropagated hyperaccumulator, Solanum nigrum L. Plant Cell Reports 28: 325-333.

50. Wang Z, Li X*. (2009). IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants. Plant Signaling & Behavior 4: 1-3.

51. Wang YN, Li KX, Li X*. (2009). Auxin redistribution modulates plastic development of root system architecture under salt stress in Arabidopsis thaliana. Journal of Plant Physiology 166: 1637-1645.

52. Wang YW, Li P, Cao XF, Wang XJ, Zhang AM, Li X*. (2009). Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochemical and Biophysical Research Communications 378: 799-803.

53. Quist T, Sokolchik I, Shi H, Joly R, Bressan R, Maggio A, Narsimhan M, Li X*. (2009). HOS3, an ELO-Like gene, inhibits effects of ABA and implicates a S-1-P/Ceramide control system for abiotic stress responses in Arabidopsis thaliana. Molecular Plant 2: 138-151.

54. Xu J, Yin H, Wang W, Mi Q, Liao X, Li X*. (2009). Identification of Cd-responsive genes of solanum nigrum seedlings through differential display. Plant Molecular Biology Reporter 27: 563-569.

55. Wang X, Gao Z, Wang Y, Bressan RA, Weller SC, Li X*. (2009). Highly efficient in vitro adventitious shoot regeneration of peppermint (Mentha x piperita L.) using internodal explants. In Vitro Cellular & Developmental Biology- Plant 45: 435-440.

56. Manabe Y, Bressan R, Wang T, Li F, Koiwa H, Sokolchik I, Li X*, Maggio A*. (2008). The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na⁺ stress. Plant Physiology 146: 612-622.

57. Sun FF, Zhang WS, Hu HZ, Li B, Wang YN, Zhao YK, Liu MY, Li X*. (2008). Salt modulates gravity signaling pathway to regulate growth direction of primary roots in Arabidopsis thaliana. Plant Physiology 146:178-188.

58. Wang YN, Zhang WS, Li KX, Sun FF, Han CY, Wang YK, Li X*. (2008). Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. Journal of Plant Research 121: 87-98.

59. Wang YN, Li X*. (2008) Salt stress-induced cell reprogramming cell fate switch and adaptive plasticity during root hair development in Arabidopsis. Plant Signaling & Behavior 3: 436 -438.

60. Li X*, Zhang WS. (2008). Salt-avoidance tropism in Arabidopsis. Plant Signaling & Behavior 3: 351-353.

61. Liu C, Wang T, Zhang WS, Li X*. (2008). Computational identification and analysis of immune-associated nucleotide gene family in Arabidopsis thaliana. Journal of Plant Physiology 165: 777-787.

62. Wang YN, Wang T, Li KX, Li X*. (2008). Genetic analysis of involvement of ETR1 in plant response to salt and osmotic stress. Plant Growth Regulation 54: 261-269.

63. Li KX#, Wang YN#, Han CY, Zhang WU, Jia H, Li X*. (2007). GA signaling and CO/FT regulatory module mediate salt-induced late flowering in Arabidopsis thaliana. Plant Growth Regulation 53: 195-206.

64. Inan G, Goto F, Jin J, A Rosado, Koiwa H, Shi H, Hasegawa PM, Bressan RA, Maggio A, Li X*. (2007). Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant Molecular Biology 65: 295-309.

65. Wang YN, Liu C, Li KX, Sun FF, Hu HZ, Li X*. (2007). Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Plant Molecular Biology 64: 633-644.

66. Zhang W, Li X, Liu JB. (2007) Genetic variation of Bmy1 alleles in barley (Hordeum vulgare L.) investigated by CAPS analysis. Theoretical Applied Genetics 114: 1039-1050.

出版书的章节

1. Liu L, Guo GY, Wang ZJ, Ji HT, Mou FP, Li X*. (2014) Auxin in plant growth and stress responses. In: Lam-Son Phan Tran and Sikander Pal (eds). Phytohormones: A window to metabolism, signaling and biotechnological application. Springer Science, New York, USA, pp1-35.

2. Zhao YK, Wang T, Zhang WS, Li X*. (2010) The role of auxin in plastic development of plant root system architecture in response to abiotic stimuli. Plant Nutrition and Abiotic Stress Tolerance. Global Science Books. Isleworth, UK, pp19-32.

本实验室秉承“快乐科研”理念，常年招收博士后、客座研究生及科研助理。欢迎对大豆共生固氮分子机制及植物抗逆机制研究感兴趣的优秀科研青年申请！欢迎各高校和研究单位同学报考本实验室硕士和博士研究生！

We are looking for highly talented and motivated candidates (postdoctoral fellows, graduate students (MSc and Ph. D.) and honors undergraduate students) to join our team, preferably with a strong background in plant molecular, cell, developmental biology and microbiology.